Nucleotide sequence of bovine acidic fibroblast growth factor cDNA
نویسندگان
چکیده
منابع مشابه
Nucleotide sequence of a rice acidic ribosomal phosphoprotein P0 cDNA.
The eukaryotic 38-kD acidic ribosomal protein PO is localized to the stalk of the 60s ribosomal subunit, forming a pentameric complex with dimers of 13-kD acidic ribosomal proteins P1 and P2 (Rich and Steitz, 1987). P1 (P2) and PO are analogous to Escherichia coli ribosomal protein L7/L12, and L10, respectively, and are thought to have the same functions as their prokaryotic counterparts, i.e. ...
متن کاملPurification and partial characterization of an acidic fibroblast growth factor from bovine pituitary.
Isoelectric focusing has allowed us to fractionate pituitary extracts into basic (pI 8-9) and acidic (pI 4-5) fibroblast growth factor. The acidic fibroblast growth factor (a) is stable upon refocusing, (b) migrates as an acidic protein in urea-containing gel electrophoresis; (c) is not cell-specific, being active with fibroblasts, adrenal, and glial cells, and (d) is a heterogeneous protein fr...
متن کاملPurification and characterization of acidic fibroblast growth factor from bovine brain.
Acidic brain fibroblast growth factor has been purified a minimum of 35,000-fold to apparent homogeneity by a combination of differential salt precipitation, ion exchange chromatography, gel filtration, isoelectric focusing, and hydrophobic chromatography on a C4 reversed-phase HPLC column. Two microheterogeneous forms of the molecule are obtained with apparent molecular masses of 16,600 and 16...
متن کاملMutagenesis of the crystal contact of acidic fibroblast growth factor
An attempt has been made to improve a crystal contact of human acidic fibroblast growth factor (haFGF; 140 amino acids) to control the crystal growth, because haFGF crystallizes only as a thin-plate form, yielding crystals suitable for X-ray but not neutron diffraction. X-ray crystal analysis of haFGF showed that the Glu81 side chain, located at a crystal contact between haFGF molecules, is in ...
متن کاملX-ray crystal structure of human acidic fibroblast growth factor.
Fibroblast growth factors (FGFs) are mitogenic and chemotactic agents for a wide variety of cell types and play a primary role in the regulation of angiogenesis. Angiogenesis is involved in a variety of critical physiological events including organogenesis, wound healing, ischemic collateral circulation, and solid tumor growth. High-resolution structural information is key to understanding the ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1988
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/16.22.10913